JWH 018 / JWH 210 Research Chemical Intermediates Powder , Legal Synthetic Cannabinoids

CAS 209414-07-3 Legit Anabolic Research Chemicals JWH 018 / 210 Cannabinoids

1. Quick Details

Chemical Nomenclature
Substitutive name JWH-018, AM-678
Systematic name Naphthalen-1-yl-(1-pentylindol-3-yl)methanone
Routes of Administration
Smoked
Dosage
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Threshold < 1 mg
Light 1 - 2 mg
Common 2 - 3 mg
Strong 3 - 5 mg
Heavy 5 mg +
Duration
Total 1 - 2 hours
Onset 5 - 10 minutes
Peak 60 - 90 minutes
Offset 5 - 10 minutes
After effects 60 - 90 minutes

2. Definition

JWH-210 is an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both the CB1 and CB2 receptors, with Ki values of 0.46nM at CB1 and 0.69nM at CB2.

JWH-018 (also called 1-pentyl-3-(1-naphthoyl)indole or AM-678). is a full agonist synthetic cannabinoid first synthesized by organic chemist John W. Huffman. It gained popularity in late 2008 when German chemists found it as a chemical within the popular synthetic cannabis blend Spice, which had been sold in numerous countries around the world since 2002.

Cannabinoids are commonly smoked or vaporized to achieve a quick onset of effects and rapid offset. JWH-018 is orally active when dissolved in a lipid, which can increase the duration significantly. Like other cannabinoids, it is insoluble in water but dissolves in ethanol and lipids.

Unlike cannabis, the chronic abuse of synthetic cannabinoids has been associated with multiple deaths and more dangerous side effects and toxicity in general. Therefore, it is strongly discouraged to take this substance for extended periods of time or in excessive doses.

3. Advantages

It is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series, having a higher binding affinity (i.e. lower Ki) at CB1 than both its 4-methyl and 4-n-propyl homologuesJWH-122 (CB1 Ki 0.69nM) and JWH-182 (CB1 Ki 0.65nM) respectively, and than the 4-methoxy compound JWH-081 (CB1 Ki 1.2nM).[2] It was discovered by and named after Dr. John W. Huffman.

JWH-210 may be neurotoxic to animals when administered in high doses.

It produces effects in animals similar to those of tetrahydrocannabinol (THC), a cannabinoid naturally present in cannabis, leading to its use in synthetic cannabis products such as "legal cannabis herbal incense blends" which in some countries are sold legally as "incense", labeled "not for human consumption

FAQ about JWH-018

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