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AH-7921 Synthetic Replacement U-47700 Powders C16H22Cl2N2O Best opioids U-49900 CAS 121348-98-9

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AH-7921 Synthetic Replacement U-47700 Powders C16H22Cl2N2O Best opioids U-49900 CAS 121348-98-9

China AH-7921 Synthetic Replacement U-47700 Powders C16H22Cl2N2O Best opioids U-49900 CAS 121348-98-9 supplier
AH-7921 Synthetic Replacement U-47700 Powders C16H22Cl2N2O Best opioids U-49900 CAS 121348-98-9 supplier AH-7921 Synthetic Replacement U-47700 Powders C16H22Cl2N2O Best opioids U-49900 CAS 121348-98-9 supplier AH-7921 Synthetic Replacement U-47700 Powders C16H22Cl2N2O Best opioids U-49900 CAS 121348-98-9 supplier AH-7921 Synthetic Replacement U-47700 Powders C16H22Cl2N2O Best opioids U-49900 CAS 121348-98-9 supplier

Large Image :  AH-7921 Synthetic Replacement U-47700 Powders C16H22Cl2N2O Best opioids U-49900 CAS 121348-98-9

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Detailed Product Description
Other Name: U-47700, U-49900 Appearance: Powder
CAS: 121348-98-9 Purity: 99%
Application: Research Purpose Package: 1kg/Aluminum Foil Bag Or As Customer's Request
Delivery Time: Within 2 Working Days Stability: 2 Years
Email: Sara@hiersunchem.com Skype: Sara@hiersunchem.com
Formula: C16H22Cl2N2O
High Light:

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AH-7921 Synthetic Replacement U-47700 Powders C16H22Cl2N2O Best opioids U-49900 CAS 121348-98-9

product details:

 

  • CAS No.: 121348-98-9
  • IUPAC.: trans-3,4-dichloro-N-(2-(dimethylamino)cyclohexyl)-N-methylbenzamide
  • Appearance: white powder
  • Formula Name: C16H22Cl2N2O
  • Molecular weight:329.265 g/mol

U-47700 was derived from AH-7921. U-47700 is selective for the µ-opioid receptor, having around 7.5 x the potency of mor.phine in animal models.

 

U-47700 is an opioid analgesic drug developed by a team at Upjohn in the 1970s that acts as a selective agonist of the µ-opioid receptor with a Kd value of 5.3 nM compared to 910 nM for the κ-opioid receptor and has around 7.5 x the potency of morphine in animal models.

 

U-47700 is a structural isomer of the earlier opioid AH-7921 and the result of a great deal of work elucidating the quantitative structure–activity relationship of the scaffold.

 

Upjohn looked for the key moieties which gave the greatest activity and posted over a dozen patents on related compounds, each optimizing one moiety until they discovered that U-47700 was the most active.

 

U-47700 became the lead compound of selective kappa-opioid receptor ligands such as U-50488, U-51754 (containing a single methylene spacer difference) and U-69,593, which share very similar structures.

Although not used medically, the selective kappa ligands are used in research.

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AH-7921 Synthetic Replacement U-47700 Powders C16H22Cl2N2O Best opioids U-49900 CAS 121348-98-9

 

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